Mandrake BioTissue-culture-free elite crop editing
Editors designed to work directly in elite plant tissue to dramatically shorten gene-editing timelines by up to 80%.
The first generation
of gene editors
was discovered.The next will
be designed from
the function up.
A full-stack protein-design company building the molecular machinery for next-generation gene editing. We design systems from scratch, around the function each application demands, rather than optimising enzymes that already exist.
Read the thesisFunction built into the design
Rather than generating proteins randomly, we encode each application's biological and biophysical requirements directly into our models, then validate function through purpose-built assays. Every result feeds the next design round. This approach is already producing double-digit experimental hit rates.
Mandrake TerraBase
On-prem, interconnected DNA-protein data with rich biological context.
0genomes
0Tbp
Function-aware generation
Proprietary sequence- and structure-aware models, post-trained on custom biological context and data.
Generative AI
Biophysics
Purpose-built assays
Functional testing in our in-house wet lab and partner network.
Our next-generation editors will enable breakthrough applications.
In vivo Gene Therapies
Editors designed around delivery from the start, enabling lower doses, simpler delivery and more accessible genetic medicines.
Research, results and open science
More results will be published soonRBX1: the only design rated Strong
12,000+ designs submitted. One Strong design. 26 nM binding affinity.
Read
Let's make life programmable
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